A new skeletal chemical kinetic mechanism of ethanol reference fuel (including ethanol, iso-octane, n-heptane, and toluene combustion mechanisms) consisting of 62 species and 194 reactions is developed for oxidation and combustion of gasoline blend surrogate fuels. The skeletal ethanol chemical kinetic mechanism is added to the toluene reference fuel (TRF) mechanism (including iso-octane, n-heptane, and toluene combustion mechanisms) using reaction paths and semidecoupling model. The ignition delay and laminar flame speed of the new combustion mechanism were modeled by using several fuel surrogates at different pressures, temperatures, and equivalence ratios. The skeletal chemical kinetic mechanism ignition delay and laminar flame speed are validated by comparison to the available experimental data of the shock tube and plate burner. The results indicate that satisfactory agreement between predictions and experimental measurements are achieved.