The quality and purity of the air entering a gas turbine is a significant factor influencing its performance and life. Foulants in the ppm range which are not captured by the air filtration system usually cause deposits on blading, which results in a severe drop in the performance of the compressor. Through the interdisciplinary approach proposed in this paper, it is possible to determine the evolution of the fouling phenomenon through the integration of studies in different research fields: (i) numerical simulation, (ii) power plant characteristics, and (iii) particle-adhesion characteristics. In fact, the size of the particles, their concentrations and adhesion ability, and filtration efficiency represent the major contributors for performing a realistic quantitative analysis of fouling phenomena in an axial compressor. The aim of this work is the estimation of actual deposits on the blade surface in terms of location and quantity. This study combines the impact/adhesion characteristic of the particles obtained through a computational fluid dynamic (CFD) and the real size distribution of the contaminants in the air swallowed by the compressor. The blade zones affected by deposits are clearly reported by using easy-to-use contaminant maps realized on the blade surface, in terms of contaminant mass. The analysis has shown that particular fluid-dynamic phenomena and airfoil shape influence the pattern deposition. The use of a filtration system decreases the contamination of blade and the charge level of electrostatic filters seems to be less important than the air contaminant concentration. From these analyses, some guidelines for proper installation and management of the power plant (in terms of filtration systems and washing strategies) can be drawn up. Characterization of the air contaminants in the power plant location represents the most important step in improving the management of the gas turbine power plant.