Accurate prediction of the vibration response of aircraft engine assemblies is of great importance when estimating both the performance and the lifetime of their individual components. In the case of underplatform dampers, for example, the motion at the frictional interfaces can lead to a highly nonlinear dynamic response and cause fretting wear at the contact. The latter will change the contact conditions of the interface and consequently impact the nonlinear dynamic response of the entire assembly. Accurate prediction of the nonlinear dynamic response over the lifetime of the assembly must include the impact of fretting wear. A multiscale approach that incorporates wear into the nonlinear dynamic analysis is proposed, and its viability is demonstrated for an underplatform damper system. The nonlinear dynamic response is calculated with a multiharmonic balance approach, and a newly developed semi-analytical contact solver is used to obtain the contact conditions at the blade–damper interface with high accuracy and low computational cost. The calculated contact conditions are used in combination with the energy wear approach to compute the fretting wear at the contact interface. The nonlinear dynamic model of the blade–damper system is then updated with the worn profile and its dynamic response is recomputed. A significant impact of fretting wear on the nonlinear dynamic behavior of the blade–damper system was observed, highlighting the sensitivity of the nonlinear dynamic response to changes at the contact interface. The computational speed and robustness of the adopted multiscale approach are demonstrated.