This paper focuses on the parametric behavior of a closed loop pulsating heat pipe in the presence of water as a working fluid. The experimental study was done in the presence of different vacuum pressures inside the heat pipe with 50 percent filling ratio. The temperature was measured through the DAQ system with help of Lab VIEW 15.1 software at 12 locations of heat pipe at variable power inputs (10W–70W). Thermal resistance and variation of temperature are used to predict the performance of the heat pipe. Thermal resistance of heat pipe decreases with decrease in vacuum pressure inside the heat pipe. This work is useful for the transfer of heat of electronic devices and integrated circuit technology due to the high coefficient of convective heat transfer in the presence of phase change of working fluid inside the heat pipe.