An investigation of airflow is essential in understanding the fate of aerosol particles in healthy and diseased lungs. Emphysema is a heterogeneous disease that results in destroyed pulmonary tissue, alveolar space enlargement and oxygen delivery impairment. A numerical model of the entire lung will assist in understanding the ventilation and aerosol deposition changes that occur with emphysema. The pulmonary airflow cannot realistically be solved in 3D for the entire lung, therefore multiscale techniques must be used to simulate dynamics by coupling 3D and 0D models.

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