Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.
1.
Nachemson
, A.
, 1962, “Some Mechanical Properties of the Lumber Intervertebral Disc
,” Bull. Hosp. Jt. Dis.
0018-5647 23
, pp. 130
–132
.2.
Bao
, Q. B.
, McCullen
, G. M.
, Higham
, P. A.
, Dubleton
, J. H.
, and Yuan
, H. A.
, 1996, “The Artificial Disc: Theory, Design and Materials
,” Biomaterials
0142-9612, 17
(12
), pp. 1157
–1166
.3.
Weber
, H.
, 1993, “Lumbar Disc Herniation: A Controlled Prospective Study with Ten Years of Observation
,” Spine
0362-2436, 8
, pp. 131
–140
.4.
Kambin
, P.
, and Savitz
, M. H.
, 2000, “Arthroscopic Microdiscectomy: An Alternative to Open Disc Surgery
,” Mt Sinai J. Med.
0027-2507, New York, 67
(4
), pp. 283
–287
.5.
Goel
, V. K.
, Goyal
, S.
, Clark
, C.
, Nishiyama
, K.
, and Nye
, T.
, 1985, “Kinematics of the Whole Lumbar Spine—Effect of Discectomy
,” Spine
0362-2436, 10
, pp. 543
–554
.6.
Tiberwal
, S. B.
, Pearcy
, M. J.
, Portek
, I.
, and Spivey
, J.
, 1985, “A Prospective Study of Lumbar Spinal Movements Before and After Discectomy Using Biplanar Radiography
,” Spine
0362-2436, 10
, pp. 455
–460
.7.
Joshi
, A.
, 2004, “Mechanical Behavior of the Human Lumbar Intervertebral Disc with a Polymeric Hydrogel Nucleus Implant: An Experimental and Finite Element Study
,” Ph.D. thesis, Drexel University, Philadelphia, PA.8.
Hickey
, A. S.
, and Peppas
, N. A.
, 1995, “Development of Semicrystalline PVA Networks for Biomedical Applications
,” J. Membr. Sci.
0376-7388, 107
(3
), pp. 229
–237
.9.
White
, A. A.
, and Panjabi
, M. M.
, 1990, Clinical Biomechanics of the Spine
, 2nd ed. JB Lippincott Co.
, Philadelphia, PA.10.
Meakin
, J. R.
, Reid
J. E.
, and Hukins
, D. W.
, 2001, “Replacing the Nucleus Pulposus of the Intervertebral Disc
,” Clin. Biomech. (Los Angel. Calif.)
0191-7870, 16
, pp. 560
–565
.11.
Frei
, H. P.
, Rathonyi
, G.
, Orr
, T. E.
, Nolte
, L. P.
, and Oxland
, T.
, 1999, “The Effect of Nucleus Prosthetic Device on the Biomechanical Behavior of the Functional Spinal Unit
,” Eur. Spine J.
0940-6719, 8
, pp. S36
–S37
.12.
Dooris
, A.
, Hudgins
, G.
, Goel
, V. K.
, Bao
, Q. B.
, and Qubo
, S.
, 2002, “Biomechanics of a Multisegmental Lumbar Spine with a Prosthetic Nucleus
,” The Spine J.
, 2
(2
), pp. 40
–41
.13.
Bain
, A. C.
, Sherman
, T.
, Norton
, B. K.
, and Hutton
, W. C.
, 2000, “A Comparison of the Viscoelastic Behavior of the Lumbar Intervertebral Disc Before and After the Implantation of a Prosthetic Disc Nucleus
,” Adv. Bioeng.
0360-9960, 48
, pp. 203
–204
.14.
Eysel
, P.
, Rompe
, J. D.
, Schoemayr
, R.
, and Zoellner
, J.
, 1999, “Biomechanical Behavior of a Prosthetic Lumbar Nucleus
,” Acta Neurochir. Suppl. (Wien)
0065-1419, 141
(10
), pp. 1083
–1087
.15.
Ledet
, E.
, Dirisio
, D.
, Tymeson
, M.
, Andersen
, L.
, Kallakury
, B.
, Sheehan
, C.
, and Sachs
, B.
, 2002, “The Raymedica PDN Prosthetic Disc Nucleus Device in the Baboon Lumbar Spine
,” The Spine J.
, 2
(5
), pp. 94
.Copyright © 2005
by American Society of Mechanical Engineers
You do not currently have access to this content.
