In recent years a diamond-like carbon (DLC) film and a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer have attracted attention as coating materials for implantable artificial organs or devices. When these materials are coated on vascular devices, compatibility to blood is an important problem. The present paper focuses on friction characteristics of erythrocytes to these coating materials in a medium. With an inclined centrifuge microscope developed by the authors, observation was made for erythrocytes moving on flat glass plates with and without coating in a medium of plasma or saline under the effect of inclined centrifugal force. Friction characteristics of erythrocytes with respect to these coating materials were then measured and compared to each other to characterize DLC and MPC as coating materials. The friction characteristics of erythrocytes in plasma using the DLC-coated and noncoated glass plates are similar, changing approximately proportional to the 0.5th power of the cell velocity. The cells stick to these plates in saline as well, implying the influence of plasma protein. The results using the MPC-coated plate in plasma are similar to those of the other plates for large cell velocities, but deviate from the other results with decreased cell velocity. The results change nearly proportional to the 0.75th power of the cell velocity in the range of small velocities. The results for the MPC-coated plate in saline are similar to that in plasma but somewhat smaller, implying that the friction characteristics for the MPC-coated plate are essentially independent of plasma protein.
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October 2008
Research Papers
Frictional Characteristics of Erythrocytes on Coated Glass Plates Subject to Inclined Centrifugal Forces
Takashi Kandori,
Takashi Kandori
Graduate School of Engineering,
Tohoku University
, 6-6 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan
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Toshiyuki Hayase,
Toshiyuki Hayase
Institute of Fluid Science,
Tohoku University
, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
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Kousuke Inoue,
Kousuke Inoue
Institute for International Advanced Interdisciplinary Research, International Advanced Research and Education Organization,
Tohoku University
, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan
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Kenichi Funamoto,
Kenichi Funamoto
Institute for International Advanced Interdisciplinary Research, International Advanced Research and Education Organization,
Tohoku University
, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan
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Takanori Takeno,
Takanori Takeno
Institute for International Advanced Interdisciplinary Research, International Advanced Research and Education Organization,
Tohoku University
, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan
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Makoto Ohta,
Makoto Ohta
Institute of Fluid Science,
Tohoku University
, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
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Motohiro Takeda,
Motohiro Takeda
Graduate School of Medicine,
Tohoku University
, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
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Atsushi Shirai
Atsushi Shirai
Institute of Fluid Science,
Tohoku University
, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
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Takashi Kandori
Graduate School of Engineering,
Tohoku University
, 6-6 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan
Toshiyuki Hayase
Institute of Fluid Science,
Tohoku University
, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
Kousuke Inoue
Institute for International Advanced Interdisciplinary Research, International Advanced Research and Education Organization,
Tohoku University
, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan
Kenichi Funamoto
Institute for International Advanced Interdisciplinary Research, International Advanced Research and Education Organization,
Tohoku University
, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan
Takanori Takeno
Institute for International Advanced Interdisciplinary Research, International Advanced Research and Education Organization,
Tohoku University
, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan
Makoto Ohta
Institute of Fluid Science,
Tohoku University
, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
Motohiro Takeda
Graduate School of Medicine,
Tohoku University
, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Atsushi Shirai
Institute of Fluid Science,
Tohoku University
, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, JapanJ Biomech Eng. Oct 2008, 130(5): 051007 (8 pages)
Published Online: July 14, 2008
Article history
Received:
August 23, 2007
Revised:
March 11, 2008
Published:
July 14, 2008
Citation
Kandori, T., Hayase, T., Inoue, K., Funamoto, K., Takeno, T., Ohta, M., Takeda, M., and Shirai, A. (July 14, 2008). "Frictional Characteristics of Erythrocytes on Coated Glass Plates Subject to Inclined Centrifugal Forces." ASME. J Biomech Eng. October 2008; 130(5): 051007. https://doi.org/10.1115/1.2948420
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