... lubrication cartilage arthritis Osteoarthritis (OA) is characterized by a loss of synovial fluid (SF) lubrication that results in higher strains on the tissue and promotes articular cartilage degradation [ 1 , 2 ], chondrocyte death [ 3 ], mitochondrial dysfunction [ 4 ], and apoptosis [ 5 , 6...

... joint and 2.1 mm for the patellofemoral joint. Model predictions of joint contact mechanics were most sensitive to changes in the material properties and geometry of the meniscus and cartilage, particularly estimates of peak contact pressure. The validated finite element modeling framework offers...

..., with the change for each test determined from experimentally measured variations in tibiofemoral alignment. The patellar tendon and the cartilage on the femur and patella were represented with springs. After loading the quadriceps, the total potential energy was minimized to determine the force within...

... of hydraulic permeability are performed accurately, and suggestions emerge for alternative measurement protocols. Insights obtained may be applied to interpretation of flow-induced deformation and related phenomena in many contexts. fluid flow deformation soft tissue cartilage gel mechanics...

.... The accuracy of the implementation is verified using 2D axisymmetric problems, including indentation with a flat-ended indenter, indentation with spherical-ended indenter, and contact of glenohumeral cartilage layers. The biphasic finite element contact formulation and its implementation are shown to be robust...

...-electrochemical properties nondestructively. Bovine knee articular cartilage and lumbar annulus fibrosus were used in this study to demonstrate that this technique could be used on different types of tissue. The results show that our newly developed method is capable of precisely predicting the water volume...

...Amanda Lim; Dmitry E. Protsenko; Brian J. F. Wong Transforming decades’ old methodology, electromechanical reshaping (EMR) may someday replace traditionally destructive surgical techniques with a less invasive means of cartilage reshaping for reconstructive and esthetic facial surgery...

...A. Seifzadeh; J. Wang; D. C. D. Oguamanam; M. Papini A nonlinear biphasic fiber-reinforced porohyperviscoelastic (BFPHVE) model of articular cartilage incorporating fiber reorientation effects during applied load was used to predict the response of ovine articular cartilage at relatively high...

...Daniel J. Woldtvedt; Wesley Womack; Benjamin C. Gadomski; Dieter Schuldt; Christian M. Puttlitz Current finite element modeling techniques utilize geometrically inaccurate cartilage distribution representations in the lumbar spine. We hypothesize that this shortcoming severely limits the predictive...

... statements can be violated at small strains. Under such conditions, a tissue with fibers aligned parallel to the direction of load initially provides the greatest resistance to compression. The results are further put into the context of a Benninghoff architecture for articular cartilage. The predictions...

... fluid bind to the cartilage surfaces through electrostatic charges, with the phospholipid layer on an articular surface supplying the necessary attractive charges. The stationary hyaluronic acid network causes a large hydrodynamic resistance to outward flow from the gap. To determine the effectiveness...

...Matthew F. Koff; Le Roy Chong; Patrick Virtue; Dan Chen; Xioanan Wang; Timothy Wright; Hollis G. Potter Different methods have been used to cross-validate cartilage thickness measurements from magnetic resonance images (MRIs); however, a majority of these methods rely on interpolated data points...

...Leo Q. Wan; X. Edward Guo; Van C. Mow Osmotic pressure and associated residual stresses play important roles in cartilage development and biomechanical function. The curling behavior of articular cartilage was believed to be the combination of results from the osmotic pressure derived from fixed...

...Seungbum Koo, PhD; Nicholas J. Giori, MD; Garry E. Gold, MD; Chris O. Dyrby; Thomas P. Andriacchi, PhD Cartilage morphology change is an important biomarker for the progression of osteoarthritis. The purpose of this study was to assess the accuracy of in vivo cartilage thickness measurements from...

..., pp. 449–457 ) to incorporate a glycosaminoglycan (GAG)-collagen (COL) stress balance using compressible elastic stress constitutive equations specific to articular cartilage (AC). For uniaxial loading of a mixture of quasilinear VE constituents, time constant and relaxation ratio equations...

... protocols thought to be advantageous for cartilage growth, less is known about the physical stimuli (e.g., pressures, velocities, and local strains) cells experience during these experiments. This study used results of a literature survey, which looked for patterns in the efficacy of mechanical stimulation...

...J. M. Huyghe; W. Wilson; K. Malakpoor The triphasic theory on soft charged hydrated tissues ( Lai, W. M., Hou, J. S., and Mow, V. C., 1991, “A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage,” ASME J. Biomech. Eng., 113, pp. 245–258 ) attributes the swelling...

...Timothy P. Ficklin; Andrew Davol; Stephen M. Klisch Recently a cartilage growth finite element model (CGFEM) was developed to solve nonhomogeneous and time-dependent growth boundary-value problems ( Davol et al., 2008, “A Nonlinear Finite Element Model of Cartilage Growth,” Biomech. Model...

.... , Hou , J. S. , and Mow , V. C. , 1991 , “ A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage...

...Narendra K. Simha; Hui Jin; Mellanie L. Hall; Sidharth Chiravarambath; Jack L. Lewis, Ph.D. Our preliminary indentation experiments showed that the equilibrium elastic modulus of murine tibial cartilage increased with decreasing indenter size: flat-ended 60 deg conical tips with end diameters of 15...