... 14 05 2014 Vascularized biological tissue has been shown to increase in stiffness with increased perfusion pressure. The interaction between blood in the vasculature and other tissue components can be modeled with a poroelastic, biphasic approach. The ability of this model to reproduce...

... poroelasticity Flow-induced deformation occurs when fluid flows through a soft tissue or gel under a hydrostatic pressure gradient, dragging the solid matrix with it. Depending upon boundary conditions, this can result in local increases or decreases in matrix compressive strain. It is a basic feature...

...Alessandro Bottaro; Tobias Ansaldi The direct infusion of an agent into a solid tumor, modeled as a spherical poroelastic material with anisotropic dependence of the tumor hydraulic conductivity upon the tissue deformation, is treated both by solving the coupled fluid/elastic equations...

... properties on the load carried by healthy (Thompson grade I) and degenerated (Thompson grades III and IV) disks. A three-dimensional parametric poroelastic finite element model of the L4/L5 motion segment was developed. Grade I, grade II, and grade IV disks were modeled by altering the biomechanical...

... the fibrils are strong in tension. The present work demonstrates the ability of the fibril reinforced poroelastic models to describe the strain rate dependent behavior of articular cartilage in unconfined compression using a mechanism of fibril stiffening mainly induced by the fluid flow. biological...

... poroelastic properties. Computational poroelastic models are then applied to compute in vitro Haversian fluid flows in a prismatic specimen of cortical bone during harmonic bending excitations over the frequency range of 10 0 to 10 6 Hz. At each frequency considered, the steady state harmonic response...

... by the Bioengineering Division August 29, 2000; revised manuscript received April 17, 2001. Associate Editor: L. A. Taber. 29 August 2000 17 April 2001 biological tissues biomechanics Cartilage Mechanics Compression-Release Poroelasticity Fibril Reinforcement Fibril Stiffening...

... measurements, and to test the prediction of biphasic and poroelastic models that tissue dimensions alter tissue stiffness through a specific scaling law for time and frequency. Disks of full-thickness adult articular cartilage from bovine humeral heads were subjected to successive applications of small...