..., 2014. Editor: Victor H. Barocas. 08 10 2013 30 12 2013 02 01 2014 Adhesive dynamics (AD) is a method for simulating the dynamic response of biological systems in response to force. Biological bonds are mechanical entities that exert force under strain, and applying forces...

... and microscale processes are poorly understood. Accordingly, the objectives of this study were to develop and use a new computational approach to determine the effects of venule tortuosity and fluid velocity on thrombus initiation. The transport, collision, shear-induced activation, and receptor-ligand adhesion...

... in translocation of transcription factor nuclear factor κ B was observed. Intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin exhibited a sustained increase in protein expression with time. The mRNA levels of these molecules were transiently upregulated and this was followed...

... a computational biomimetic approach to study cell crawling assisted by contractile stress induced de-adhesion at the rear of the focal adhesion zone (FAZ). We assume the formation of the FAZ is driven by receptor-ligand bonds and nonspecific interactions. The contractile stress is generated due to the molecular...

... of hemodynamic forces in plaque initiation. Vascular cell adhesion molecule-1 (VCAM-1) was examined as an indicator of plaque growth, as it participates in monocyte adhesion, which is one of the initial steps in the formation of fatty lesions. The hemodynamics of a healthy right and left coronary artery were...

...Jaewoo Shim; Hiromi Nakamura; Takahiro Ogawa; Vijay Gupta A previously developed laser spallation technique to determine the tensile strength of thin film interfaces was successfully adopted to study the effect of microsurface roughness of titanium disks on the adhesion strength of mineralized bone...

..., we found the shape of the membrane in all three regions over a range of tether lengths and forces observed in experiments. We also analyze the effects of biophysical properties of the membrane, including the bending modulus and the forces of the membrane adhesion to the cytoskeleton. The model’s...

...–18% of the thickness of the abdominal aortic media, which forms a pronounced cohesive zone at the dissection front. adhesion biomechanics blood vessels failure analysis stress analysis tensile strength The experimental data from tensile tests on aortas indicate that they are dependent...

... (i.e., linearly elastic and noninteractive probe-sample pairs) indentation of soft, inhomogeneous materials. In the presence of probe-sample adhesive interactions, which are common especially during retraction of the rigid tip from soft materials, the Hertzian models are no longer adequate. A number...

... and subsequent sustained adhesion. However, further investigation has been limited by the lack of experimental models that allow quantitative measurement of the hydrodynamic environment over adherent cells. The purpose of this study was to develop a system capable of acquiring quantitative flow profiles over...

... rigidity of a cell with nonlinear mechanical properties is deduced from the mechanical response of the entire population of adherent cells. The proposed hyperelastic cell model successfully accounts for the variability in probe-cell geometrical features, and the influence of the cell–substrate adhesion...

...Ronald P. Jean; Christopher S. Chen; Alexander A. Spector Endothelial cells possess a mechanical network connecting adhesions on the basal surface, the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can deform the nucleus, ultimately resulting in an alteration...

...Ronald P. Jean; Darren S. Gray; Alexander A. Spector; Christopher S. Chen We investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations of cell shape as cells...

... the micro-pockets. In this way, a poro-elasto-hydrodynamic regime of lubrication is developed. Assuming that lower friction would result in lower adhesive wear, and neglecting the fatigue as well as the abrasive wear, the proposed bearing system hypothetically could reduce the amount of wear debris...

...; revised manuscript received April 2002. Associate Editor: C. Dong. 01 September 2001 01 April 2002 30 07 2002 cellular biophysics haemodynamics biological techniques biomembranes haemorheology blood adhesion Tethers are long membrane tubes extracted from cell...

... of radiation adhesion It is now widely recognized that biological functions of cells are dependent upon or regulated by the mechanical environment, i.e. , the extracellular matrix and neighboring cells 1 2 3 4 5 6 7 . In adherent living cells, interactions...

.... , 75B ( 3 ), pp. 459 – 463 . prosthetics bone fracture mechanics finite element analysis orthopaedics biomechanics adhesion Debonding of the cement-bone interface in cemented total joint replacements is considered to be an important cause...

... 2001. Associate Editor: V. T. Turitto. 01 07 2000 01 05 2001 29 03 2002 porous materials adhesion cellular biophysics biological techniques biological fluid dynamics biomedical materials In this note, we report the design and characterization...

... of embryonic cells, and total or partial engulfment, separation and dissociation of tissues. This broadly-based theory accounts for the action of all currently known cytoskeletal components and cell adhesion mechanisms. The theory is used to derive conditions for the cell and tissue rearrangements named above...

...Mark E. Zobitz; Chunfeng Zhao; Peter C. Amadio; Kai-Nan An The technique of surgical repair for zone two flexor tendon injuries has been debated extensively throughout the years, yet adhesion formation, suture rupture, and suture locking on the pulley edge remain possible consequences of a poor...