... a novel methodology of incorporating helical air-nanoparticle streams for pulmonary nanotherapeutics, using a customized version of the open-source computational fluid dynamics (CFD) toolbox openfoam . As nanoparticles predominantly follow streamlines, helical airflow transports them in a centralized core...

... nanoparticles play an important role in the development of targeted drug delivery due to their unique physicochemical properties. Particle size has a significant impact on the circulation time, biodistribution, and drug accumulation. Smaller particles (50–300 nm) have slower removal from the circulation [ 47...

...Aili Zhang; Yingxue Guan; Lisa X. Xu Cellular uptake kinetics of nanoparticles is one of the key issues determining the design and application of the particles. Models describing nanoparticles intrusion into the cell mostly take the endocytosis process into consideration, and the influences...

... the tests on the scaffold mechanical properties as they degrade. To validate the developed model, scaffolds were made from the biocompatible polymer polycaprolactone (PCL) mixed with hydroxylapatite (HA) nanoparticles and their mechanical properties were examined in terms of the Young modulus. Based...

..., polycaprolactone nanofiber scaffolds with spatially controlled concentrations of β -tricalcium phosphate nanoparticles were fabricated using twin-screw extrusion-electrospinning process and seeded with MC3T3-E1 cells to form osteochondral tissue constructs. The objective of the study was to evaluate the linear...

...Emily S. Day; Jennifer G. Morton; Jennifer L. West Advances in nanotechnology are enabling many new diagnostic and therapeutic approaches in cancer. In this review, examples where nanoparticles are employed to induce localized heating within tumors are explored. Approaches to nanoparticle-mediated...

...Chao Chen; Aili Zhang; Xiaodong Zhang; Jun Hu; Lisa X. Xu Gold nanoparticles have been found to greatly enhance the polymerase chain reaction (PCR) specificity and yield in recent studies. However, the underlying mechanism is still unclear, though different hypotheses have already been proposed...

... , employing an experimentally validated computer model. The TB tree was geometrically decomposed into triple-bifurcation units with kinematically adjusted multilevel outlet/inlet conditions. Deposition patterns and maximum concentrations differ greatly between nanoparticles ( 1 ⩽ d p ⩽ 150 nm ) and micron...

...Jinxiang Xi; P. Worth Longest The deposition of ultrafine aerosols in the respiratory tract presents a significant health risk due to the increased cellular-level response that these particles may invoke. However, the effects of geometric simplifications on local and regional nanoparticle...

...H. Shi; C. Kleinstreuer; Z. Zhang The transport and deposition of nanoparticles, i.e., d p = 1 – 2 nm , or equivalent vapors, in the human nasal cavities is of interest to engineers, scientists, air-pollution regulators, and healthcare officials alike. Tiny ultrafine particles, i.e., d p ≤ 5 nm...