We describe a specific implementation of the Biodesign process explained by Zenios et al. and how it may be adapted for use in small teams in an academic or corporate setting. This adaptation is termed disciplined innovation to place emphasis on the rigorous information mining that must occur to truly understand the problem prior to contemplating design solutions. We provide a roadmap with links to online resources for the purpose of navigating the initial stages of the Biodesign process, specifically “Needs Finding” and “Needs Screening.”