Polymeric ultrathin films, also called nanofilms or nanosheets, show peculiar properties making them potentially useful for several applications in biomedicine, e.g., as nanoplasters for localized drug release or as a new solution for closing endoluminal surgical wounds. In this sense, one of most challenging issues is film control in the working environment: the possibility of including magnetic components, such as magnetic nanoparticles or nanotubes, paves the way for the effective use of nanofilms in the human body, by allowing precise positioning by an external magnetic field. State of the art and new perspectives of magnetic nanofilms for biomedical applications are here presented, including fabrication, modeling, characterization and validation.

Issue Section:
Research Paper
Keywords:
biomedical materials, magnetic particles, magnetic thin films, nanobiotechnology, nanomagnetics, nanoparticles, nanotubes, polymer films
Topics:
Biomedicine, Drugs, Manufacturing, Modeling, Nanoparticles, Nanotubes, Magnetic fields, Surgery, Wounds
1.
Fujie
,
T.
,
Okamura
,
Y.
, and
Takeoka
,
S.
, 2007, “
Ubiquitous Transference of a Free-Standing Polysaccharide Nanosheet With the Development of a Nano-Adhesive Plaster
,”
Adv. Mater.
0935-9648,
19
(
21
), pp.
3549
–
3553
.
Crossref
Search ADS
 
2.
Okamura
,
Y.
,
Utsunomiya
,
S.
,
Suzuki
,
H.
,
Niwa
,
D.
,
Osaka
,
T.
, and
Takeoka
,
S.
, 2008, “
Fabrication of Free-Standing Nanoparticle-Fused Nanosheets and Their Hetero-Modification Using Sacrificial Film
,”
Colloids Surf., A
0927-7757,
318
(
1–3
), pp.
184
–
190
.
3.
Gorbunov
,
V.
,
Fuchigami
,
N.
,
Stone
,
M.
,
Grace
,
M.
, and
Tsukruk
,
V. V.
, 2002, “
Biological Thermal Detection: Micromechanical and Microthermal Properties of Biological Infrared Receptors
,”
Biomacromolecules
1525-7797,
3
(
1
), pp.
106
–
115
.
Crossref
Search ADS
PubMed
 
4.
Fuchigami
,
N.
,
Hazel
,
J.
,
Gorbunov
,
V. V.
,
Stone
,
M.
,
Grace
,
M.
, and
Tsukruk
,
V. V.
, 2001, “
Biological Thermal Detection in Infrared Imaging Snakes. 1. Ultramicrostructure of Pit Receptor Organs
,”
Biomacromolecules
1525-7797,
2
(
3
), pp.
757
–
764
.
Crossref
Search ADS
PubMed
 
5.
Fujie
,
T.
,
Okamura
,
Y.
, and
Takeoka
,
S.
, 2009, “
Selective Surface Modification of Free-Standing Polysaccharide Nanosheet With Micro/Nano-Particles Identified by Structural Color Changes
,”
Colloids Surf., A
0927-7757,
334
(
1–3
), pp.
28
–
33
.
6.
Lin
,
Y. -H.
,
Jiang
,
C.
,
Xu
,
J.
,
Lin
,
Z.
, and
Tsukruk
,
V. V.
, 2007, “
Sculptured Layer-by-Layer Films
,”
Adv. Mater.
0935-9648,
19
(
22
), pp.
3827
–
3832
.
Crossref
Search ADS
 
7.
Sano
,
K. -I.
,
Sasaki
,
H.
, and
Shiba
,
K.
, 2006, “
Utilization of the Pleiotropy of a Peptidic Aptamer to Fabricate Heterogeneous Nanodot-Containing Multilayer Nanostructures
,”
J. Am. Chem. Soc.
0002-7863,
128
(
5
), pp.
1717
–
1722
.
Crossref
Search ADS
PubMed
 
8.
Zhai
,
L.
,
Cebeci
,
F. Ç.
,
Cohen
,
R. E.
, and
Rubner
,
M. F.
, 2004, “
Stable Superhydrophobic Coatings From Polyelectrolyte Multilayers
,”
Nano Lett.
1530-6984,
4
(
7
), pp.
1349
–
1353
.
Crossref
Search ADS
 
9.
Tang
,
Z.
,
Wang
,
Y.
,
Podsiadlo
,
P.
, and
Kotov
,
N. A.
, 2006, “
Biomedical Applications of Layer-by-Layer Assembly: From Biomimetics to Tissue Engineering
,”
Adv. Mater.
0935-9648,
18
(
24
), pp.
3203
–
3224
.
Crossref
Search ADS
 
10.
Shaikh Mohammed
,
J.
,
Decoster
,
M. A.
, and
Mcshane
,
M. J.
, 2006, “
Fabrication of Interdigitated Micropatterns of Self-Assembled Polymer Nanofilms Containing Cell-Adhesive Materials
,”
Langmuir
0743-7463,
22
(
6
), pp.
2738
–
2746
.
Crossref
Search ADS
PubMed
 
11.
Ai
,
H.
,
Meng
,
H.
,
Ichinose
,
I.
,
Jones
,
S. A.
,
Mills
,
D. K.
,
Lvov
,
Y. M.
, and
Qiao
,
X.
, 2003, “
Biocompatibility of Layer-by-Layer Self-Assembled Nanofilm on Silicone Rubber for Neurons
,”
J. Neurosci. Methods
0165-0270,
128
(
1–2
), pp.
1
–
8
.
PubMed
 
12.
2009,
Magnetic Nanosheet Adhesion to Mucosal Tissue
,
Pensabene
,
V.
,
Mattoli
,
V.
,
Menciassi
,
A.
,
Dario
,
P.
,
Fujie
,
T.
, and
Takeoka
,
S.
, eds.,
IEEE
,
Genoa, Italy
, pp.
403
–
407
.
13.
Lehman
,
A. C.
,
Berg
,
K. A.
,
Dumpert
,
J.
,
Wood
,
N. A.
,
Visty
,
A. Q.
,
Rentschler
,
M. E.
,
Platt
,
S. R.
,
Farritor
,
S. M.
, and
Oleynikov
,
D.
, 2008, “
Surgery With Cooperative Robots
,”
Comput. Aided Surg.
1092-9088,
13
(
2
), pp.
95
–
105
.
Crossref
Search ADS
PubMed
 
14.
Kalloo
,
A. N.
,
Singh
,
V. K.
,
Jagannath
,
S. B.
,
Niiyama
,
H.
,
Hill
,
S. L.
,
Vaughn
,
C. A.
,
Magee
,
C. A.
, and
Kantsevoy
,
S. V.
, 2004, “
Flexible Transgastric Peritoneoscopy: A Novel Approach to Diagnostic and Therapeutic Interventions in the Peritoneal Cavity
,”
Gastrointest. Endosc.
0016-5107,
60
(
1
), pp.
114
–
117
.
Crossref
Search ADS
PubMed
 
15.
2010,
Magnetic Nanosheet Manipulation: Modeling, Development and Validation
,
Mattoli
,
V.
,
Sinibaldi
,
E.
,
Pensabene
,
V.
,
Taccola
,
S.
,
Menciassi
,
A.
, and
Dario
,
P.
, eds.,
IEEE
,
Anchorage, AK
.
16.
Lvov
,
Y.
,
Decher
,
G.
, and
Moehwald
,
H.
, 1993, “
Assembly, Structural Characterization, and Thermal Behavior of Layer-by-Layer Deposited Ultrathin Films of Poly(Vinyl Sulfate) and Poly(Allylamine)
,”
Langmuir
0743-7463,
9
(
2
), pp.
481
–
486
.
Crossref
Search ADS
 
17.
Jiang
,
H.
,
Su
,
W.
,
Hazel
,
J.
,
Grant
,
J. T.
,
Tsukruk
,
V. V.
,
Cooper
,
T. M.
, and
Bunning
,
T. J.
, 2000, “
Electrostatic Self-Assembly of Sulfonated C60-Porphyrin Complexes on Chitosan Thin Films
,”
Thin Solid Films
0040-6090,
372
(
1–2
), pp.
85
–
93
.
18.
Mattoli
,
V.
,
Pensabene
,
V.
,
Fujie
,
T.
,
Taccola
,
S.
,
Menciassi
,
A.
,
Takeoka
,
S.
, and
Dario
,
P.
, 2009, “
Fabrication and Characterization of Ultra-Thin Magnetic Films for Biomedical Applications
,”
Procedia Chemistry
,
1
(
1
), pp.
28
–
31
.
Crossref
Search ADS
 
19.
Palagi
,
S.
, 2009, “
Study and Development of a Magnetic Steering System for Microrobots
,” M.D. thesis, University of Pisa, Pisa, Italy.
20.
White
,
F. M.
, 2005,
Viscous Fluid Flow
,
McGraw-Hill Series in Mechanical Engineering
,
McGraw-Hill
,
New York
.
Copyright © 2009
 by American Society of Mechanical Engineers
You do not currently have access to this content.