As the development of offshore oil and gas continues to move into deeper waters, the risers connecting the seabed infrastructure to the offshore platform are getting longer. This means that vortex-induced vibration (VIV) may occur at different frequencies along the riser due to current variation, making the VIV prediction challenging. To increase the VIV prediction accuracy, an empirical time-domain VIV model has been developed. The advantage of the model is that it can account for structural non-linearities such as variable tension and time-varying flow. The robustness of the time-domain VIV model has been verified with respect to the several tests, but the length/diameter (L/D) ratio of the risers used in the experiments has so far been relatively small, and the response mode number accordingly low. Therefore, additional validation is needed to understand the uncertainties for the prediction of VIV for deep-sea riser systems at high-mode order. The purpose of the present study was to evaluate the use of time-domain model for high-mode VIV response prediction of deep-sea riser systems. This was done by a comparison study applying the Hanøytangen high-mode VIV test data. The main comparison was made regarding the dominating frequency and fatigue damage estimation. For selected empirical parameters, the model demonstrated a good correlation with the experiments. However, the simplified riser model that was utilized in the simulations caused some discrepancies between numerical simulations and the experimental results, which need to be further investigated.