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Jay D. Humphrey
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Journal Articles

Remodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery

Abhay B. Ramachandra, Bo Jiang, Isabella R. Jennings, Edward P. Manning, Jay D. Humphrey
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2024, 146(8): 084501.
Paper No: BIO-23-1201
https://doi.org/10.1115/1.4064967
Published Online: March 21, 2024
View Article titled, Remodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery
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Topics: Pulmonary artery, Pressure, Biomechanics, Stiffness
Includes: Supplementary data
Journal Articles

Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice

Abhay B. Ramachandra, Nicole Mikush, Maor Sauler, Jay D. Humphrey, Edward P. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2022, 144(8): 081008.
Paper No: BIO-21-1330
https://doi.org/10.1115/1.4053873
Published Online: March 11, 2022
View Article titled, Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice
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Topics: Fibers, Lung, Pressure, Pulmonary artery, Stress, Ventilation, Energy storage, Stiffness, Diseases, Vessels
Includes: Supplementary data
Journal Articles

Reduced Smooth Muscle Contractile Capacity Facilitates Maladaptive Arterial Remodeling

John F. Eberth, Jay D. Humphrey
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2022, 144(4): 044503.
Paper No: BIO-21-1188
https://doi.org/10.1115/1.4052888
Published Online: December 15, 2021
View Article titled, Reduced Smooth Muscle Contractile Capacity Facilitates Maladaptive Arterial Remodeling
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Topics: Carotid arteries, Muscle, Pressure, Stress, Wall thickness, Stiffness, Biomechanics, Energy storage, Vessels, Aorta
Journal Articles

Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility

Alexander W. Caulk, Jay D. Humphrey, Sae-Il Murtada
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2019, 141(3): 031008.
Paper No: BIO-18-1174
https://doi.org/10.1115/1.4042171
Published Online: January 25, 2019
View Article titled, Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility
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Topics: Muscle, Testing, Stress
Journal Articles

Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts

Jason M. Szafron, Christopher K. Breuer, Yadong Wang, Jay D. Humphrey
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2017, 139(12): 121008.
Paper No: BIO-17-1149
https://doi.org/10.1115/1.4037856
Published Online: September 28, 2017
View Article titled, Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts
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Topics: Stress, Design, Biological tissues
Journal Articles

Novel Methodology for Characterizing Regional Variations in the Material Properties of Murine Aortas

Matthew R. Bersi, Chiara Bellini, Paolo Di Achille, Jay D. Humphrey, Katia Genovese, Stéphane Avril
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2016, 138(7): 071005.
Paper No: BIO-15-1515
https://doi.org/10.1115/1.4033674
Published Online: June 7, 2016
View Article titled, Novel Methodology for Characterizing Regional Variations in the Material Properties of Murine Aortas
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Topics: Aorta, Fibers, Materials properties, Pressure, Stress, Testing, Mechanical testing, Stiffness, Uncertainty, Diseases
Includes: Supplementary data
Journal Articles

Computational Simulation of the Adaptive Capacity of Vein Grafts in Response to Increased Pressure

Abhay B. Ramachandra, Sethuraman Sankaran, Jay D. Humphrey, Alison L. Marsden
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2015, 137(3): 031009.
Paper No: BIO-14-1128
https://doi.org/10.1115/1.4029021
Published Online: March 1, 2015
View Article titled, Computational Simulation of the Adaptive Capacity of Vein Grafts in Response to Increased Pressure
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Topics: Pressure, Stress, Simulation, Vessels
Proceedings Papers

Modelling Dynamical Arterial Adaptations to Altered Chemo-Mechanical Environments

Luca Cardamone, Arturo Valentin, Jay D. Humphrey
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 927-928, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192097
https://doi.org/10.1115/SBC2008-192097
View Paper titled, Modelling Dynamical Arterial Adaptations to Altered Chemo-Mechanical Environments
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Topics: Dynamics (Mechanics), Endothelial cells, Fibroblasts, Modeling, Muscle, Particle filtering (numerical methods), Sheet molding compound (Plastics), Sliding mode control, Surface mount components
Proceedings Papers

A Framework for Fluid-Solid-Growth Modeling and its Application to Understanding the Enlargement of a Fusiform Aneurysm

Seungik Baek, C. Alberto Figueroa, Charles A. Taylor, Jay D. Humphrey
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 961-962, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192805
https://doi.org/10.1115/SBC2008-192805
View Paper titled, A Framework for Fluid-Solid-Growth Modeling and its Application to Understanding the Enlargement of a Fusiform Aneurysm
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Topics: Aneurysms, Fluids, Modeling, Fluid structure interaction, Biomechanics, Biological fluid dynamics, Blood vessels, Boundary-value problems, Cardiac cycle, Geometry
Proceedings Papers

Biomechanics of the Human Anterior Lens Capsule

Ryan M. Pedrigi, Jay D. Humphrey
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 1013-1014, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192073
https://doi.org/10.1115/SBC2008-192073
View Paper titled, Biomechanics of the Human Anterior Lens Capsule
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Topics: Biomechanics, Lenses (Optics), Finite element methods, Stress, Biological tissues, Surgery, Design, Diabetes, Mechanical behavior, Mechanical properties
Proceedings Papers

Incorporating the Effects of Variable Wall Properties in Large-Scale Deformable Models of the Cardiovascular System

C. Alberto Figueroa, Seungik Baek, Jay D. Humphrey, Charles A. Taylor
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 427-428, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176686
https://doi.org/10.1115/SBC2007-176686
View Paper titled, Incorporating the Effects of Variable Wall Properties in Large-Scale Deformable Models of the Cardiovascular System
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Topics: Biological tissues, Blood, Blood flow, Blood vessels, Boundary-value problems, Cardiovascular system, Computer simulation, Degrees of freedom, Design, Diseases
Proceedings Papers

Computational Growth and Remodeling Model for Evolving Tissue Engineered Vascular Grafts in the Venous Circulation

Kristin S. Miller, Brooks V. Udelsman, Yong-Ung Lee, Yuji Naito, Christopher K. Breuer, Jay D. Humphrey
Proc. ASME. FMD2013, ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, V001T07A004, September 11–13, 2013
Publisher: American Society of Mechanical Engineers
Paper No: FMD2013-16168
https://doi.org/10.1115/FMD2013-16168
View Paper titled, Computational Growth and Remodeling Model for Evolving Tissue Engineered Vascular Grafts in the Venous Circulation
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Topics: Biological tissues, Polymers, Mechanical behavior, Optimization, Pressing, Stress, Tissue engineering
Proceedings Papers

Growth and Remodeling of Vein Graft in an Arterial Environment: Parameter Estimation and Sensitivity Analysis

Abhay B. Ramachandra, Sethuraman Sankaran, Jay D. Humphrey, Alison L. Marsden
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT28A009, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14617
https://doi.org/10.1115/SBC2013-14617
View Paper titled, Growth and Remodeling of Vein Graft in an Arterial Environment: Parameter Estimation and Sensitivity Analysis
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Topics: Blood vessels, Coronary arteries, Design, Diseases, Failure, Flow (Dynamics), Geometry, Hemodynamics, High pressure (Physics), Parameter estimation
Proceedings Papers

A Growth and Remodeling Approach to AAA Modeling: Feasibility and Initial Insights

John S. Wilson, Seungik Baek, Jay D. Humphrey
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 63-64, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53525
https://doi.org/10.1115/SBC2011-53525
View Paper titled, A Growth and Remodeling Approach to AAA Modeling: Feasibility and Initial Insights
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Topics: Aneurysms, Biomedical imaging, Modeling, Risk, Rupture, Surgery
Journal Articles

Stress Distribution in a Circular Membrane With a Central Fixation

Daisuke Mori, Guido David, Jay D. Humphrey, James E. Moore, Jr.
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. June 2005, 127(3): 549–553.
https://doi.org/10.1115/1.1894389
Published Online: January 31, 2005
View Article titled, Stress Distribution in a Circular Membrane With a Central Fixation
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Topics: Biological tissues, Membranes, Stress, Stress concentration, Differential equations, Boundary-value problems
Journal Articles

A Sub-Domain Inverse Finite Element Characterization of Hyperelastic Membranes Including Soft Tissues

Padmanabhan Seshaiyer, Jay D. Humphrey
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. June 2003, 125(3): 363–371.
https://doi.org/10.1115/1.1574333
Published Online: June 10, 2003
View Article titled, A Sub-Domain Inverse Finite Element Characterization of Hyperelastic Membranes Including Soft Tissues
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Topics: Finite element analysis, Finite element methods, Membranes, Soft tissues, Stress, Boundary-value problems, Equilibrium (Physics)
Journal Articles

Stress-Modulated Growth, Residual Stress, and Vascular Heterogeneity

Larry A. Taber, Jay D. Humphrey
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. December 2001, 123(6): 528–535.
https://doi.org/10.1115/1.1412451
Published Online: July 25, 2001
View Article titled, Stress-Modulated Growth, Residual Stress, and Vascular Heterogeneity
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Topics: Stress
Journal Articles

Effects of Heat-Induced Damage on the Radial Component of Thermal Diffusivity of Bovine Aorta

Sean E. Davis,, David J. Doss,, Jay D. Humphrey,, Neil T. Wright
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. June 2000, 122(3): 283–286.
https://doi.org/10.1115/1.429658
Published Online: February 6, 2000
View Article titled, Effects of Heat-Induced Damage on the Radial Component of Thermal Diffusivity of Bovine Aorta
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Topics: Aorta, Damage, Heat, Thermal diffusivity, Soft tissues, Heating, Temperature, Biological tissues