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Spencer E. Szczesny
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Journal Articles

The Elephant in the Cell: Nuclear Mechanics and Mechanobiology

Michelle L. Jones, Kris Noel Dahl, Tanmay P. Lele, Daniel E. Conway, Vivek Shenoy, Soham Ghosh, Spencer E. Szczesny
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Review Articles
J Biomech Eng. August 2022, 144(8): 080802.
Paper No: BIO-21-1401
https://doi.org/10.1115/1.4053797
Published Online: March 11, 2022
View Article titled, The Elephant in the Cell: Nuclear Mechanics and Mechanobiology
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Topics: Biological tissues, Computer simulation, Deformation, Mechanical properties, Mechanobiology, Modeling, Proteins, Shapes, Tension, Stress
Journal Articles

A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants

Krishna Pedaprolu, Spencer E. Szczesny
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2022, 144(8): 084505.
Paper No: BIO-21-1377
https://doi.org/10.1115/1.4053795
Published Online: March 9, 2022
View Article titled, A Novel, Open-Source, Low-Cost Bioreactor for Load-Controlled Cyclic Loading of Tendon Explants
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Topics: Biological tissues, Bioreactors, Stress, Tendons, Fatigue
Includes: Supplementary data
Journal Articles

The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction

Spencer E. Szczesny, Robert L. Mauck
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2017, 139(2): 021006.
Paper No: BIO-16-1276
https://doi.org/10.1115/1.4035350
Published Online: January 19, 2017
View Article titled, The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction
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Topics: Fibers, Membranes, Proteins, Stiffness, Stress, Tension, Deformation, Cell membranes, Cellular mechanics, Stem cells
Proceedings Papers

Evidence for Interfibrillar Shear Load Transfer Between Sliding Fibrils in Tendon

Spencer E. Szczesny, Dawn M. Elliott
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT48A006, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14677
https://doi.org/10.1115/SBC2013-14677
View Paper titled, Evidence for Interfibrillar Shear Load Transfer Between Sliding Fibrils in Tendon
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Topics: Shear (Mechanics), Stress, Tendons, Biological tissues, Shear stress, Bearings, Microscopy, Stiffness, Viscosity
Proceedings Papers

Mucopolysaccharidosis VII and the Developing Lumbar Spine: Consequences for Annulus Fibrosus and Vertebral End Plate Mechanical Properties

Lachlan J. Smith, John T. Martin, Spencer E. Szczesny, Katherine P. Ponder, Mark E. Haskins, Dawn M. Elliott
Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 1243-1244, June 17–21, 2009
Publisher: American Society of Mechanical Engineers
Paper No: SBC2009-206489
https://doi.org/10.1115/SBC2009-206489
View Paper titled, Mucopolysaccharidosis VII and the Developing Lumbar Spine: Consequences for Annulus Fibrosus and Vertebral End Plate Mechanical Properties
Open the PDF for Mucopolysaccharidosis VII and the Developing Lumbar Spine: Consequences for Annulus Fibrosus and Vertebral End Plate Mechanical Properties in another window
Topics: Annulus, Diseases, Enzymes, Lumbar spine, Mechanical properties, Pediatrics, Scoliosis
Proceedings Papers

Material Properties Over-Estimated by Boundary Conditions in Biaxial Tension Can Be Corrected Using Finite Element Analysis

Nathan T. Jacobs, Daniel H. Cortes, Spencer E. Szczesny, Edward J. Vresilovic, Dawn M. Elliott
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 515-516, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80616
https://doi.org/10.1115/SBC2012-80616
View Paper titled, Material Properties Over-Estimated by Boundary Conditions in Biaxial Tension Can Be Corrected Using Finite Element Analysis
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Topics: Boundary-value problems, Finite element analysis, Materials properties, Tension, Fibers, Biological tissues, Errors, Modeling, Soft tissues, Stress
Proceedings Papers

Tunable Hyaluronic Acid Hydrogels to Alter and Understand Left Ventricular Remodeling

Elena Tous, Jamie L. Ifkovits, Shauna M. Dorsey, Spencer E. Szczesny, Kevin J. Koomalsingh, Takashi Shuto, Toru Soeda, Joseph H. Gorman, III, Dawn M. Elliott, Robert C. Gorman, Jason A. Burdick
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1013-1014, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80284
https://doi.org/10.1115/SBC2012-80284
View Paper titled, Tunable Hyaluronic Acid Hydrogels to Alter and Understand Left Ventricular Remodeling
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Topics: Biological tissues, Coronary arteries, Diseases, Heart failure, Hydrogels, Myocardium, Patient treatment, Stress
Proceedings Papers

Continuity and Affine Fiber Kinematics in Biaxial Tension of the Supraspinatus Tendon

Spencer E. Szczesny, John Peloquin, Sarah Ilkhani-Pour, Daniel H. Cortes, Jennifer A. Kadlowec, Louis J. Soslowsky, Dawn M. Elliott
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 659-660, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53588
https://doi.org/10.1115/SBC2011-53588
View Paper titled, Continuity and Affine Fiber Kinematics in Biaxial Tension of the Supraspinatus Tendon
Open the PDF for Continuity and Affine Fiber Kinematics in Biaxial Tension of the Supraspinatus Tendon in another window
Topics: Fibers, Kinematics, Tendons, Tension, Boundary-value problems, Materials properties, Biological tissues, Deformation, Stress, Tensile testing
Journal Articles

Biaxial Tensile Testing and Constitutive Modeling of Human Supraspinatus Tendon

Spencer E. Szczesny, John M. Peloquin, Daniel H. Cortes, Jennifer A. Kadlowec, Louis J. Soslowsky, Dawn M. Elliott
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2012, 134(2): 021004.
https://doi.org/10.1115/1.4005852
Published Online: March 19, 2012
View Article titled, Biaxial Tensile Testing and Constitutive Modeling of Human Supraspinatus Tendon
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Topics: Biological tissues, Fibers, Stress, Tendons, Testing, Sensitivity analysis, Parameter estimation, Tensile testing, Errors, Constitutive equations
Journal Articles

In Situ Deformations in the Immature Brain During Rapid Rotations

Nicole G. Ibrahim, Rahul Natesh, Spencer E. Szczesny, Karen Ryall, Stephanie A. Eucker, Brittany Coats, Susan S. Margulies
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2010, 132(4): 044501.
https://doi.org/10.1115/1.4000956
Published Online: March 10, 2010
View Article titled, In Situ Deformations in the Immature Brain During Rapid Rotations
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Topics: Biological tissues, Brain, Deformation, Wounds, Errors
Proceedings Papers

Design of a Gimbaled Compliant Mechanism Stage for Precision Motion and Dynamic Control in Z, Θ X and Θ Y Directions

Spencer E. Szczesny, Amos G. Winter, V
Proc. ASME. IDETC-CIE2004, Volume 2: 28th Biennial Mechanisms and Robotics Conference, Parts A and B, 1535-1540, September 28–October 2, 2004
Publisher: American Society of Mechanical Engineers
Paper No: DETC2004-57589
https://doi.org/10.1115/DETC2004-57589
View Paper titled, Design of a Gimbaled Compliant Mechanism Stage for Precision Motion and Dynamic Control in Z, Θ X and Θ Y Directions
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Topics: Compliant mechanisms, Design, Resonance, Stiffness, Bending (Stress), Finite element analysis, Diaphragms (Mechanical devices), Diaphragms (Structural), Dynamic testing (Engineering), Dynamic testing (Materials)